Journal article
Protocol for a randomized controlled trial evaluating the effect of physical activity on delaying the progression of white matter changes on MRI in older adults with memory complaints and mild cognitive impairment: The AIBL Active trial
EV Cyarto, NT Lautenschlager, PM Desmond, D Ames, C Szoeke, O Salvado, MJ Sharman, KA Ellis, PM Phal, CL Masters, CC Rowe, RN Martins, KL Cox
BMC Psychiatry | Published : 2012
Abstract
Background: Older adults free of dementia but with subjective memory complaints (SMC) or mild cognitive impairment (MCI) are considered at increased risk of cognitive decline. Vascular risk factors (VRF), including hypertension, heart disease, smoking, hypercholesterolemia and lack of physical activity (PA) have been identified as modifiable risk factors contributing to cognitive decline, and white matter hyperintensities (WMH) are associated with VRF, SMC and cognitive impairment. Findings from a growing number of clinical trials with older adults are providing strong evidence for the benefits of physical activity for maintaining cognitive function, but few studies are investigating these b..
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Grants
Awarded by Science and Industry Endowment Fund
Funding Acknowledgements
[ "We are most grateful to all volunteers taking part in the study and to our research staff. This project is supported by a project grant from Australia's National Health and Medical Research Council (1005942) to NL, PD, KC, DA, CS, OS, KE, PP, CM, CR and RM.", "Funding for the AIBL study is provided by the CSIRO Flagship Collaboration Fund and the Science and Industry Endowment Fund (SIEF) in partnership with Edith Cowan University (ECU), Mental Health Research institute (MHRI), Alzheimer's Australia (AA), National Ageing Research Institute (NARI), Austin Health, CogState Ltd., Hollywood Private Hospital, Sir Charles Gardner Hospital. The study also receives funding from the National Health and Medical Research Council, the Dementia Collaborative Research Centres program (DCRC2) and The McCusker Alzheimer's Research Foundation and Operational Infrastructure Support from the Government of Victoria." ]